Endocrine Disruptors and Plastics.

Dangerous Plastics, Safe Plastics
From toys to water bottles, we're all surrounded by dangerous plastics. Here’s how to choose safe plastics.

By Linda B. White, M.D.
August/September 2009

You’ve been out — working, exercising, shopping. You open the car door and slip into the ovenlike interior. Throat dry, you reach for the water bottle that’s been sitting in the cup holder all day. It’s warm. But at least it’s water, right? Water, yes, albeit water potentially spiked with chemicals that migrated out of the plastic — chemicals that aren’t good for your health.

The latest scientific research has given us a lot of good reasons to think carefully about how we use plastics. The main concern with several types of plastic is that they contain endocrine disruptors — substances that, when taken into our bodies, alter normal hormonal function. Over the past several years, scientists and the media have struggled to find answers to mysteries such as precocious puberty, declining fertility rates in otherwise healthy adults, hyperactivity in kids, the fattening of America, and the persistent scourges of prostate cancer and breast cancer.

Although multiple factors play a role in all of these conditions, one recurrent theme is the brew of endocrine disruptors infiltrating our lives.

Effects of Endocrine Disruptors

Endocrine disruptors (which are now widespread in food, water, soil and even the air we breathe) include a long list of chemicals such as dioxins, cadmium, parabens, bisphenol A, phthalates, polychlorinated biphenyls (PCBs), agricultural chemicals, polybrominated flame retardants, and some of the active ingredients in sunscreens.
Many of these chemicals cause problems because they can mimic the action of natural estrogen.

These foreign estrogens (also known as xenoestrogens) can upset normal hormonal balance, stimulate the growth and development of reproductive tumors (breast, uterine, prostate), impair fertility, and disrupt pregnancy. Worse, many can cross the placenta to affect the fetus and get into breast milk.

Chemicals such as phthalates have an antiandrogenic effect, meaning they interfere with testosterone and other hormones responsible for male sex characteristics. Exposure to these agents during fetal life and early childhood can derail normal sexual development and heighten the risk for diseases that don’t become apparent until adulthood, such as cancer.

Problems with BPA

One of the most troubling endocrine disruptors is a common ingredient in plastic called bisphenol A (commonly called BPA). According to Laura N. Vandenberg, who holds a doctorate in cell, molecular and developmental biology and works at the Center for Developmental and Regenerative Biology at Tufts University, “BPA is one of the highest volume chemicals produced worldwide, with over 6 billion pounds produced each year.”

Used to produce polycarbonate plastics and epoxy resins, BPA is found in many drinking containers, the lining of most food and beverage cans (including soda cans), bottle caps, plastic cutlery, plastic food storage containers, toys, dental sealants, some dental composites, water pipes, eyeglass lenses, and more.

Polycarbonate is often blended with other plastics to create products such as mobile phone cases, car parts, electronic equipment, medical equipment, and household items. Because BPA is in printer ink, newspapers, and carbonless receipts, most recycled paper contains it, including paper towels and paper used to contain food.

The problem is that BPA migrates from the plastic into neighboring substances such as food, water, and saliva. Heat, contact with acidic (think vinegar or soda), and alkaline (think baking soda) substances, and repeated washing of polycarbonate plastics accelerate the process. BPA also leaches into groundwater from plastics piled in landfills.

Although most of our intake is dietary, BPA can also be inhaled, and can move across the skin into our blood by means of bath water.
Because it is so pervasive, we all have BPA on board.
One study by the Centers for Disease Control and Prevention found BPA in 95 percent of urine samples.
It’s also present in blood, amniotic fluid, fetal tissues, ovarian fluid, and breast milk.
Infants and small children take in more BPA than adults because — relative to their size — they breathe, drink and eat more, put everything within reach into their mouths, and don’t clear the chemical from their bodies as fast as adults.

Information on the potential dangers of BPA comes mostly from animal research. In lab rats and mice, even low doses during early development alter the reproductive hormone cycles in males and females. Specifically, females have earlier puberty, increased mammary (breast) development, prolonged estrous cycles (the equivalent of menstrual cycles), chromosomal abnormalities in their eggs, and other fertility problems.

Males have decreased testosterone levels, fewer and less motile sperm, more abnormal sperm, increased prostate size, and changes reflecting a heightened risk for prostate cancer. In some studies, both males and females tend to weigh more and have more body fat. Exposure during fetal development can alter brain structure and function, and lead to subsequent behavioral changes, such as increased aggressiveness, impaired motor activity, anxious behavior, and impaired learning.

Risk assessment reports before 2004 — particularly those funded by groups such as the American Plastics Council — dismissed the dangers to humans on the grounds that levels in humans fell short of the concentrations that caused ill effects in test-tube and animal studies.

However, Frederick vom Saal, who holds a doctorate in neurobiology and is a prominent researcher and professor at the University of Missouri, notes that of the 115 low-dose BPA studies published by the end of 2004, 94 found estrogen-like effects in animals. More pointedly, he says, “No industry funded studies have reported significant effects of low doses of BPA, although more than 90 percent of government funded studies have reported significant effects.”

In 2007, the University of North Carolina’s Chapel Hill Bisphenol A Expert Panel, which included Vandenberg and 38 other experts, published a report stating that human exposure levels are well within the range that has proven harmful to rats and mice.

Furthermore, these adverse effects in lab animal studies mirror health conditions that have been on the rise in humans over the past 50 years: infertility, breast and prostate cancer, type-2 diabetes, obesity, attention deficit disorder, cardiovascular diseases, autism, and abnormal development of the penis. More research is needed to confirm these correlations.

Despite the Panel’s report, the U.S. National Toxicology Program’s (NTP) Center for the Evaluation of Risks to Human Reproduction issued a brief in April 2008 that fell short of sounding the alarm. In June 2008, the NTP Board of Scientific Counselors further downgraded some of the potential risks. In a nutshell, the NTP voiced “some concern” for neural and behavioral effects and effects on the prostate gland in fetuses, infants and children at current exposures.

For the same age group, they said there is “minimal concern” about effects on the breast and on earlier puberty in girls. For adults, the concern about exposures adversely affecting pregnancy outcomes or the health of reproductive organs was “negligible.”
Among the long list of experts that responded to the NTP brief, the American Academy of Pediatrics said the report’s downplaying of the risks, particularly for infants and pregnant women, would falsely reassure the public. Sarah Janssen, science fellow for the Natural Resources Defense Council, responded to the brief more bluntly: “BPA should be considered a hazard to human development and reproduction with clear evidence of adverse effects.”

While the U.S. Food and Drug Administration maintains current levels of BPA are safe for humans, the Canadian government declared BPA toxic in April 2008, triggering a ban on the use of BPA in baby bottles.

But in October, a group of scientific advisers to the U.S. FDA rejected the assessment, stating that the agency had ignored crucial studies and employed flawed methods in its research. As the FDA risk assessment continues, some states are proposing legislation that would ban many plastics containing BPA.

Trouble with Phthalates

Phthalates represent another ubiquitous category of endocrine disruptors. Used to soften plastic, these chemicals pop up in PVC-containing plastic products, including:
• children’s toys
• personal care products (cosmetics, nail polish, hair spray, deodorant, shampoos, body washes, perfumes)
• air fresheners
• insect repellents
• detergents and other cleaning products
• lubricants
• vinyl products (shower curtains, raincoats, vinyl flooring)
• medical equipment (tubing, bags for intravenous fluids, vinyl gloves)
• the plastic in breast pumps
• the outer coating on many pills
• garden hoses
• pool liners
• modeling clay
• food packaging

With respect to pacifiers and baby bottle nipples, most companies have switched to latex- and silicone-based materials in their manufacturing.

Because phthalates aren’t tightly bound to plastics, they readily migrate into neighboring substances such as food, water, air, and saliva. Phthalates are thus present in our urine, blood, breast milk, saliva, amniotic fluid, and seminal fluid.
The biggest health concern is reproductive toxicity — particularly for males.

Numerous animal studies link phthalate exposure during fetal development with malformations of parts of the male reproductive system. Reports of ill effects in females aren’t as numerous, although higher levels of these chemicals have been associated with early breast development in girls and endometriosis in women.

Phthalates in indoor air have been associated with asthma and allergic conditions.
In 2005, the European Union banned three phthalate compounds from children’s toys and other children’s products.

California has passed a law limiting exposure to di(2-ethylhexyl) phthalate (commonly known as DEHP). And Minnesota, Maryland, Maine, and Oregon have proposed similar legislation. Washington state recently passed the Children’s Safe Products Act to protect kids from exposure to lead, cadmium and phthalates.
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Keeping BPA Out of Food and Beverages

In addition to the potential health risks, there are many more reasons to reduce your use of plastic food containers, dishes, and cutlery. Plastics consume resources that are largely nonrenewable (crude oil and natural gas), their use contributes to needless waste, and their production and degradation create pollution. Here are a few BPA safety tips for food and drink.
• Can the cans. “Canned foods are likely to be the highest contributor to BPA in our diets, not plastics,” says Vandenberg. Also, she says parents should buy powdered rather than liquid infant formula, because the former has less exposure to the BPA lining the can.
• If you use plastic wrap, try to find one that doesn’t contain BPA. Vandenberg says the trouble is that companies are not required to tell you what’s in plastic wrap, adding, “Studies show that many stretch wraps contain BPA and other endocrine disruptors.”
• Warm and store food in ceramic or glass containers. The label “microwave safe” on a plastic food container only means that the plastic won’t melt. If the product contains BPA, it will leach into your food faster when warm.
• Make sure baby bottles, pacifiers and toys for infants and toddlers are BPA-free.
• Avoid bottled water, especially in plastic bottles. According to Food & Water Watch, bottled water is more expensive and no safer than tap water. In fact, it is often bottled tap water.
• Use metal or wooden utensils when you cook. Use wooden rather than plastic cutting boards, and clean thoroughly after use.
• Bring your own, BPA-free containers for leftovers and take-away foods.
• Recycle. Plastic containers and packaging are clogging our landfills and leaching endocrine disruptors into groundwater, plus marring the landscape and injuring wildlife.
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How to Avoid Phthalates

Avoiding phthalates is challenging because manufacturers aren’t required to list them as product ingredients.
• Look for “phthalate-free” on the label of personal care products (especially nail polish). For information on product ingredients, check the Campaign for Safe Cosmetics website.
• Use fragrance-free detergents, cleansers and personal care products. Artificial fragrances commonly use diethyl phthalate (DEP).
• Avoid products made of vinyl plastic usually labelled as No. 3 (raincoats, shower curtains) and polyvinyl chloride (PVC pipe, other building materials, some lawn furniture, and some children’s and pets’ toys).
Note: In 2007, the Natural Resources Defense Council tested 14 common air fresheners. Although none of them listed phthalates as an ingredient, 12 of the 14 contained these chemicals, including those advertised as unscented or “all natural.” Read the NRDC's full report on phthalates and air fresheners.
You can find links to the reference materials for this article in the Plastics and Endocrine Disruptors Article Resources, below. Plus, follow FDA reviews and regulation updates.